Founder members Great Horton announced their resignation from the JCT600 Bradford League at tonight's annual meeting at Pudsey Congs.
The Division Two club survived a re-election vote in 2013 but their fortunes improved on the field during the 2014 season with their first and second teams both finishing sixth in their respective divisions.
The club had been set a number of objectives to improve facilities at their Ewart Street Ground and had engaged with a series of progress meetings with members of the league's Management Board.
Chief executive David Young, who read out the brief letter of resignation which was submitted by club stalwart Tony Hamer, said: "It is extremely sad to be losing a club who were founder members of this league.
"We do not like losing clubs at any time and we thank Great Horton for the contribution they have made over their 111 years in the league."
Great Horton were a dominant force in the early years of the Bradford League. They won the league title four times in 1904, 1906, 1908 and 1909 and lifted the Priestley Cup in 1906, 1909, and 1911.
After winning seven trophies in seven years, Great Horton went 103 years without winning another major award.